ViaDermFMG™ is a patent-pending rapid dermal delivery system, designed to carry the active ingredients directly to the desired site. IbuCream™ is an OTC topical cream, containing ViaDerm FMG™, rapidly delivering ibuprofen USP, lidocaine, MSM, rosemary and other proprietary ingredients to painful areas.

ViaDermFMG™ may be licensed to pharmaceutical and cosmetic firms to deliver active agents in a transdermal delivery system.

IbuCream™ can be used up to 4 times a day for chronic pain or just once daily for acute trauma or inflammation of muscles, tendons, ligaments, joints, heel spurs, gout, and other local pain management applications. Within minutes, anti-inflammatory pain support is being provided for up to 2-4 hours or more. Natural rosemary's light scent provides immediate cooling effects and the scent disappears within minutes.

Benefits of Topical Creams

• Topical delivery offers advantages over oral administration:

1) Use smaller amounts of active ingredients
2) Avoid liver metabolism
3) Avoid degradation of active ingredients in the g. i. tract
4) No stomach upset

• Delivery System of the Future

Doctors around the world are calling topical creams "the delivery system of the future." It has been discovered that a high absorption rate of many NSAIDs and pain-alleviating herbal extracts can be achieved when delivered through the skin.

While your skin acts as a barrier to water-soluble applications, fats have been proven to pass through the skin and carry pain relief to inflamed soft tissue, such as muscle, ligament, and tendon.

• Under Your Skin

The first layer of skin [epidermis] consists of laminated layers of epithelial cells which slows the evaporation of water from the inside. Its surface [stratum corneum] is a network of furrows of different sizes.

Under the epidermis is the thickest layers of skin [dermis] which are rich in sebaceous and sweat glands, fat cells, lymph, blood vessels and nerves.

• Factors Affecting Skin Penetration

1) Oil solubility: the more oil soluble [lipophilic] the substance, the greater
    the skin penetration.
2) The lower the molecular weight the smaller the molecule.
3) Creams, gels and liquids penetrate better than solids.
4) Penetration enhancers improve topical absorption of lipophilic
    substances.


• 95% Delivery

Studies have shown that when NSAIDs and nutrients are taken orally, as little as 5% make it to the area of inflammation where they are needed. This is because of the stomach, liver and digestive system re-arranging and discarding much of them.


• Summary

Our proprietary "Patch Free" cream base technology, ViaDerm FMG™, containing exclusive Penetration Enhancers, offers a safer, quick-acting, and easier-to-comply alternative to capsules and tablets.


• References

J Pharm Sci "Linear relationships between lipophilic character and biological activity of drugs."1972 Jan;61(1):1-19

Targeted drug delivery to the skin and deeper tissues: role of physiology, solute structure and disease.Clin Exp Pharmacol Physiol 1997 Nov;24(11):874-9